Catching sight of lysosomes

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Catching sight of lysosomes

174 The invention of freeze fracture EM and the determination of membrane structure Catching sight of lysosomes ll we wanted was to know something about the localization of glucose-6phosphatase, which we thought might provide a possible clue to the mechanism of action, or lack of action, of insulin on the liver cell.” Thus begins Christian de Duve’s discovery of lysosomes, which he first visual...

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Lysosomes

I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...

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Lysosomes

Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....

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" Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness, a development that experts called a major advance for the experimental technique, " said the Gainsville Sun in Florida, the state in which the results were announced at a meeting last month. It's a story that excited many news editors with a number of angles to heighten ...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2005

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1682fta1